The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer's Disease During the COVID-19 Crisis.
Identifieur interne : 000473 ( Main/Exploration ); précédent : 000472; suivant : 000474The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer's Disease During the COVID-19 Crisis.
Auteurs : Claire Boutoleau-Bretonnière [France] ; Hélene Pouclet-Courtemanche [France] ; Aurelie Gillet [France] ; Amelie Bernard [France] ; Anne Laure Deruet [France] ; Ines Gouraud [France] ; Aurelien Mazoue [France] ; Estelle Lamy [France] ; Laetitia Rocher [France] ; Dimitrios Kapogiannis [États-Unis] ; Mohamad El Haj [France]Source :
- Journal of Alzheimer's disease : JAD [ 1875-8908 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (psychologie), Infections à coronavirus (épidémiologie), Maladie d'Alzheimer (psychologie), Maladie d'Alzheimer (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (psychologie), Pneumopathie virale (épidémiologie), Quarantaine (psychologie), Quarantaine (tendances), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tests de l'état mental et de la démence (MeSH), Troubles mentaux (psychologie), Troubles mentaux (épidémiologie), Études de cohortes (MeSH).
- MESH :
- psychologie : Infections à coronavirus, Maladie d'Alzheimer, Pneumopathie virale, Quarantaine, Troubles mentaux.
- tendances : Quarantaine.
- épidémiologie : Infections à coronavirus, Maladie d'Alzheimer, Pneumopathie virale, Troubles mentaux.
- Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Mâle, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests de l'état mental et de la démence, Études de cohortes.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Alzheimer Disease (epidemiology), Alzheimer Disease (psychology), Betacoronavirus (MeSH), Cohort Studies (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (psychology), Female (MeSH), Humans (MeSH), Male (MeSH), Mental Disorders (epidemiology), Mental Disorders (psychology), Mental Status and Dementia Tests (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (psychology), Quarantine (psychology), Quarantine (trends).
- MESH :
- epidemiology : Alzheimer Disease, Coronavirus Infections, Mental Disorders, Pneumonia, Viral.
- psychology : Alzheimer Disease, Coronavirus Infections, Mental Disorders, Pneumonia, Viral, Quarantine.
- trends : Quarantine.
- Aged, Aged, 80 and over, Betacoronavirus, Cohort Studies, Female, Humans, Male, Mental Status and Dementia Tests, Middle Aged, Pandemics.
Abstract
BACKGROUND
Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation, and hallucinations, are frequent in Alzheimer's disease (AD) and their prevalence tends to increase with external stressors.
OBJECTIVE
We offer the first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD.
METHODS
We contacted caregivers of 38 patients with AD who were confined to their homes for nearly two months and asked them to report whether patients experienced any change in neuropsychiatric symptoms during, compared to before, the confinement and rate its severity and impact on themselves using the Neuropsychiatric Inventory-Questionnaire.
RESULTS
Among the 38 patients, only 10 demonstrated neuropsychiatric changes during the confinement. Cognitive function of these 10 patients, assessed with the Mini-Mental State Examination, was worse than that of patients who did not demonstrate neuropsychiatric changes. Interestingly, among the 10 patients with neuropsychiatric changes, the duration of confinement significantly correlated with the severity of symptoms as well as with their caregivers' distress.
DISCUSSION
The confinement seems to impact neuropsychiatric symptomatology in AD patients with low baseline cognitive function.
DOI: 10.3233/JAD-200604
PubMed: 32568211
Affiliations:
Links toward previous steps (curation, corpus...)
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xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Rocher, Laetitia" sort="Rocher, Laetitia" uniqKey="Rocher L" first="Laetitia" last="Rocher">Laetitia Rocher</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, 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Kapogiannis</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="El Haj, Mohamad" sort="El Haj, Mohamad" uniqKey="El Haj M" first="Mohamad" last="El Haj">Mohamad El Haj</name><affiliation wicri:level="3"><nlm:affiliation>Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing</wicri:regionArea><wicri:noRegion>Tourcoing</wicri:noRegion><wicri:noRegion>Tourcoing</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut Universitaire de France, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Universitaire de France, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno 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xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Pouclet Courtemanche, Helene" sort="Pouclet Courtemanche, Helene" uniqKey="Pouclet Courtemanche H" first="Hélene" last="Pouclet-Courtemanche">Hélene Pouclet-Courtemanche</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Gillet, Aurelie" sort="Gillet, Aurelie" uniqKey="Gillet A" first="Aurelie" last="Gillet">Aurelie Gillet</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amelie" last="Bernard">Amelie Bernard</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Deruet, Anne Laure" sort="Deruet, Anne Laure" uniqKey="Deruet A" first="Anne Laure" last="Deruet">Anne Laure Deruet</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Gouraud, Ines" sort="Gouraud, Ines" uniqKey="Gouraud I" first="Ines" last="Gouraud">Ines Gouraud</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Mazoue, Aurelien" sort="Mazoue, Aurelien" uniqKey="Mazoue A" first="Aurelien" last="Mazoue">Aurelien Mazoue</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Lamy, Estelle" sort="Lamy, Estelle" uniqKey="Lamy E" first="Estelle" last="Lamy">Estelle Lamy</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Rocher, Laetitia" sort="Rocher, Laetitia" uniqKey="Rocher L" first="Laetitia" last="Rocher">Laetitia Rocher</name><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Inserm CIC04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Kapogiannis, Dimitrios" sort="Kapogiannis, Dimitrios" uniqKey="Kapogiannis D" first="Dimitrios" last="Kapogiannis">Dimitrios Kapogiannis</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="El Haj, Mohamad" sort="El Haj, Mohamad" uniqKey="El Haj M" first="Mohamad" last="El Haj">Mohamad El Haj</name><affiliation wicri:level="3"><nlm:affiliation>Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing</wicri:regionArea><wicri:noRegion>Tourcoing</wicri:noRegion><wicri:noRegion>Tourcoing</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut Universitaire de France, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Universitaire de France, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="eISSN">1875-8908</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Alzheimer Disease (epidemiology)</term><term>Alzheimer Disease (psychology)</term><term>Betacoronavirus (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (psychology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mental Disorders (epidemiology)</term><term>Mental Disorders (psychology)</term><term>Mental Status and Dementia Tests (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (psychology)</term><term>Quarantine (psychology)</term><term>Quarantine (trends)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (psychologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maladie d'Alzheimer (psychologie)</term><term>Maladie d'Alzheimer (épidémiologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (psychologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Quarantaine (psychologie)</term><term>Quarantaine (tendances)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Tests de l'état mental et de la démence (MeSH)</term><term>Troubles mentaux (psychologie)</term><term>Troubles mentaux (épidémiologie)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Alzheimer Disease</term><term>Coronavirus Infections</term><term>Mental Disorders</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladie d'Alzheimer</term><term>Pneumopathie virale</term><term>Quarantaine</term><term>Troubles mentaux</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Alzheimer Disease</term><term>Coronavirus Infections</term><term>Mental Disorders</term><term>Pneumonia, Viral</term><term>Quarantine</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Quarantaine</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Quarantine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladie d'Alzheimer</term><term>Pneumopathie virale</term><term>Troubles mentaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status and Dementia Tests</term><term>Middle Aged</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests de l'état mental et de la démence</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation, and hallucinations, are frequent in Alzheimer's disease (AD) and their prevalence tends to increase with external stressors.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We offer the first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We contacted caregivers of 38 patients with AD who were confined to their homes for nearly two months and asked them to report whether patients experienced any change in neuropsychiatric symptoms during, compared to before, the confinement and rate its severity and impact on themselves using the Neuropsychiatric Inventory-Questionnaire.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among the 38 patients, only 10 demonstrated neuropsychiatric changes during the confinement. Cognitive function of these 10 patients, assessed with the Mini-Mental State Examination, was worse than that of patients who did not demonstrate neuropsychiatric changes. Interestingly, among the 10 patients with neuropsychiatric changes, the duration of confinement significantly correlated with the severity of symptoms as well as with their caregivers' distress.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>The confinement seems to impact neuropsychiatric symptomatology in AD patients with low baseline cognitive function.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32568211</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-8908</ISSN><JournalIssue CitedMedium="Internet"><Volume>76</Volume><Issue>1</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Journal of Alzheimer's disease : JAD</Title><ISOAbbreviation>J. Alzheimers Dis.</ISOAbbreviation></Journal><ArticleTitle>The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer's Disease During the COVID-19 Crisis.</ArticleTitle><Pagination><MedlinePgn>41-47</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JAD-200604</ELocationID><Abstract><AbstractText Label="BACKGROUND">Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation, and hallucinations, are frequent in Alzheimer's disease (AD) and their prevalence tends to increase with external stressors.</AbstractText><AbstractText Label="OBJECTIVE">We offer the first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD.</AbstractText><AbstractText Label="METHODS">We contacted caregivers of 38 patients with AD who were confined to their homes for nearly two months and asked them to report whether patients experienced any change in neuropsychiatric symptoms during, compared to before, the confinement and rate its severity and impact on themselves using the Neuropsychiatric Inventory-Questionnaire.</AbstractText><AbstractText Label="RESULTS">Among the 38 patients, only 10 demonstrated neuropsychiatric changes during the confinement. Cognitive function of these 10 patients, assessed with the Mini-Mental State Examination, was worse than that of patients who did not demonstrate neuropsychiatric changes. Interestingly, among the 10 patients with neuropsychiatric changes, the duration of confinement significantly correlated with the severity of symptoms as well as with their caregivers' distress.</AbstractText><AbstractText Label="DISCUSSION">The confinement seems to impact neuropsychiatric symptomatology in AD patients with low baseline cognitive function.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boutoleau-Bretonnière</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pouclet-Courtemanche</LastName><ForeName>Hélene</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gillet</LastName><ForeName>Aurelie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernard</LastName><ForeName>Amelie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deruet</LastName><ForeName>Anne Laure</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gouraud</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazoue</LastName><ForeName>Aurelien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lamy</LastName><ForeName>Estelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocher</LastName><ForeName>Laetitia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CHU Nantes, Inserm CIC04, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Nantes, Départementde Neurologie, Centre Mémoire de Ressources et Recherche, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kapogiannis</LastName><ForeName>Dimitrios</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El Haj</LastName><ForeName>Mohamad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Universitaire de France, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Alzheimers Dis</MedlineTA><NlmUniqueID>9814863</NlmUniqueID><ISSNLinking>1387-2877</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001523" MajorTopicYN="N">Mental Disorders</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073216" MajorTopicYN="N">Mental Status and Dementia Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011790" MajorTopicYN="N">Quarantine</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Alzheimer’s disease</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">confinement</Keyword><Keyword MajorTopicYN="Y">neuropsychiatric symptoms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32568211</ArticleId><ArticleId IdType="pii">JAD200604</ArticleId><ArticleId IdType="doi">10.3233/JAD-200604</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Maryland</li><li>Pays de la Loire</li><li>Île-de-France</li></region><settlement><li>Nantes</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Boutoleau Bretonniere, Claire" sort="Boutoleau Bretonniere, Claire" uniqKey="Boutoleau Bretonniere C" first="Claire" last="Boutoleau-Bretonnière">Claire Boutoleau-Bretonnière</name></region><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amelie" last="Bernard">Amelie Bernard</name><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amelie" last="Bernard">Amelie Bernard</name><name sortKey="Boutoleau Bretonniere, Claire" sort="Boutoleau Bretonniere, Claire" uniqKey="Boutoleau Bretonniere C" first="Claire" last="Boutoleau-Bretonnière">Claire Boutoleau-Bretonnière</name><name sortKey="Deruet, Anne Laure" sort="Deruet, Anne Laure" uniqKey="Deruet A" first="Anne Laure" last="Deruet">Anne Laure Deruet</name><name sortKey="Deruet, Anne Laure" sort="Deruet, Anne Laure" uniqKey="Deruet A" first="Anne Laure" last="Deruet">Anne Laure Deruet</name><name sortKey="El Haj, Mohamad" sort="El Haj, Mohamad" uniqKey="El Haj M" first="Mohamad" last="El Haj">Mohamad El Haj</name><name sortKey="El Haj, Mohamad" sort="El Haj, Mohamad" uniqKey="El Haj M" first="Mohamad" last="El Haj">Mohamad El Haj</name><name sortKey="El Haj, Mohamad" sort="El Haj, Mohamad" uniqKey="El Haj M" first="Mohamad" last="El Haj">Mohamad El Haj</name><name sortKey="Gillet, Aurelie" sort="Gillet, Aurelie" uniqKey="Gillet A" first="Aurelie" last="Gillet">Aurelie Gillet</name><name sortKey="Gouraud, Ines" sort="Gouraud, Ines" uniqKey="Gouraud I" first="Ines" last="Gouraud">Ines Gouraud</name><name sortKey="Gouraud, Ines" sort="Gouraud, Ines" uniqKey="Gouraud I" first="Ines" last="Gouraud">Ines Gouraud</name><name sortKey="Lamy, Estelle" sort="Lamy, Estelle" uniqKey="Lamy E" first="Estelle" last="Lamy">Estelle Lamy</name><name sortKey="Lamy, Estelle" sort="Lamy, Estelle" uniqKey="Lamy E" first="Estelle" last="Lamy">Estelle Lamy</name><name sortKey="Mazoue, Aurelien" sort="Mazoue, Aurelien" uniqKey="Mazoue A" first="Aurelien" last="Mazoue">Aurelien Mazoue</name><name sortKey="Pouclet Courtemanche, Helene" sort="Pouclet Courtemanche, Helene" uniqKey="Pouclet Courtemanche H" first="Hélene" last="Pouclet-Courtemanche">Hélene Pouclet-Courtemanche</name><name sortKey="Pouclet Courtemanche, Helene" sort="Pouclet Courtemanche, Helene" uniqKey="Pouclet Courtemanche H" first="Hélene" last="Pouclet-Courtemanche">Hélene Pouclet-Courtemanche</name><name sortKey="Rocher, Laetitia" sort="Rocher, Laetitia" uniqKey="Rocher L" first="Laetitia" last="Rocher">Laetitia Rocher</name><name sortKey="Rocher, Laetitia" sort="Rocher, Laetitia" uniqKey="Rocher L" first="Laetitia" last="Rocher">Laetitia Rocher</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Kapogiannis, Dimitrios" sort="Kapogiannis, Dimitrios" uniqKey="Kapogiannis D" first="Dimitrios" last="Kapogiannis">Dimitrios Kapogiannis</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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